Name of screen:	Screen type:	Supplier:	Legend:	Composition:	Product number:
Classic I Suite	Define crystallization conditions of soluble protein, pH(4.6-9.0)	Qiagen			130701
Classic II Suite	Define crystallization conditions of soluble protein, pH(3.5-8.5)	Qiagen			130723
JCSG Core Suite I	Define crystallization conditions of a new protein based on the JCSG	Qiagen			130724
JCSG Core Suite II	Define crystallization conditions of a new protein based on the JCSG	Qiagen			130725
JCSG Core Suite III	Define crystallization conditions of a new protein based on the JCSG	Qiagen			130726
JCSG Core Suite IV	Define crystallization conditions of a new protein based on the JCSG	Qiagen			130727
JCSG+ Suite	Define crystallization conditions of a new protein based on the JCSG	Qiagen			130720
Pi-minimal_HTS screen	Based on a novel combinations of precipitants, buffers and additives condition for the screening of soluble proteins. pH(4.0-9.5)	Jena Bioscience			CS-211L
Morpheus_HT-96	Simple and effective 3D grid design covering a range of pH, PEGs and salt additives. 49 low molecular weight ligands observed to promote initial crystal formation.	Molecular Dimensions			MD1-47
Morpheus-II_HT-96	Morpheus II is a follow-up to the best-selling 96-condition screen, Morpheus	Molecular Dimensions			MD1-92
Clear Strategy_HT-96 Screen I	Define crystallization conditions of soluble protein. Maintain ‘folding homogeneity’ of protein. pH(5.5 / 6.5 / 7.5 / 8.5)	Molecular Dimensions			MD1-31
Clear Strategy_HT-96 Screen II	Define crystallization conditions of soluble protein. Maintain ‘folding homogeneity’ of protein. pH(5.5 / 6.5 / 7.5 / 8.5)	Molecular Dimensions			MD1-32
MemGold_HT-96	Membrane protein screen based on the Protein Data Bank. PEGs and salt additives. Based on 130 membrane protein structures in the PDB. Covering a range of pH(5.2-8.5)	Molecular Dimensions			MD1-41
MemGold2_HT-96	This screen targets all alpha helical types of Prokaryotic and Eukaryotic membrane proteins	Molecular Dimensions			MD1-64
Screen Membrane HTS	72 of the most successful buffers for crystallization of membrane proteins	Jena Bioscience			CS-305L
LMB Crystallization Screen	A 96 conditions sparse matrix screen based on optimised and published condtitions from the LMB-MRC, Cambridge UK.	Molecular Dimensions			MD1-99

(available on demand, contact the facility)

Name of screen:	Screen type:	Supplier:	Legend:	Composition:	Product number:
Clear Strategy™ Screen I	24 stock solutions testing a range of salts and PEGs. User should provides 4 x 1M buffers allowing full control of the pH.	Molecular Dimensions			130704
Clear Strategy™ Screen II	24 stock solutions testing a range of salts, organic solutions, cations, PEG 4000 together with calcium acetate. User should provides 4 x 1M buffers allowing full control of the pH.	Molecular Dimensions			130716

Name of screen:	Screen type:	Supplier:	Legend:	Composition:	Product number:
PEGs Suite	Test a wide range of PEG molecular weights (200 up to 20000) and four different pH value. Test also the effect of PEG 3350 with a wide spectrum of low concentration salts	Qiagen			130704
PEGs II Suite	Use polyethylene glycols of varying molecular weights	Qiagen			130716
AmSO4 Suite	For refinement of promising conditions containing AmSO4	Qiagen			130705
PACT Suite	Different combinations of PEGs and ions to test effect of anions and cations and pH	Qiagen			130718
pHClear Suite I	For systematic analysis of precipitant concentration and pH(4-9)	Qiagen			130709
pHClear Suite II	For systematic analysis of precipitant concentration and pH(4-9)	Qiagen			130705
Protein Complex Suite	Optimized for protein-protein complex	Qiagen			130715
Nucleix Suite	Suited for protein-nucleic acid complex	Qiagen			130719
Pentaerythritol_HTS	Based on pentaerythritol polymers as precipitants. 4 polymers that differ from MPD and PEG's in size and nature. pH(4.6 / 6.5 / 7.5 / 8.5)	Jena Bioscience			CS-210L
MIDAS_HT-96	Based on alternative polymeric precipitants. Salt and pH centred on physiological values. Ideal for protein and complexes. Designed to complement PEG and alt based-screens.	Molecular Dimensions			MD1-60
PGA LM_HT-96	Based on poly-?-glutamic acid polymer as precipitant suitable for both globular and membrane protein crystallization. Non-denaturating conditions. pH(5 / 6.5 / 7.8)	Molecular Dimensions			MD1-51

Name of screen:	Screen type:	Supplier:	Legend:	Composition:	Product number:
Cubic Screen	The LCP method works especially well when traditional methods have failed to yield crystals.	Jena Bioscience			CS-EB-LCP-B
MemMeso HT-96	Designed to work in synergy with Lipidic Cubic Phase	Molecular Dimensions			MD1-87

(available on demand, contact the facility)

Name of screen:	Screen type:	Supplier:	Legend:	Composition:	Product number:
Additive_screen	96 unique additives and their ability to influence the crystallization	Hampton Research			HR2-428
MemAdvantage	An additive screen developed exclusively for membrane proteins. This screen targets all alpha helical types of Prokaryotic and Eukaryotic membrane proteins	Molecular Dimensions			MD1-70

Customized user screens

How do I decide which screens to use?

How do I overcome screen redundacy?

The C6 is a webtool which aims to simplify the crystallization landscape by showing the relationship between the different screens, and help you select an appropriate subset of the screens that we have available. C6 provides a list of all the currently available commercial screens and a breakdown on the individual contents of each well. You can use the C6 webtool also to find screens that contain a condition that you know your protein likes (or something very close). For example the literature may suggest that similar proteins have crystallised rapidly in ammonium sulfate and low MW PEGs, using the C6 Webtool you can search for all screens that contain conditions with these chemicals.